Importance Of Pyrimidine Nucleotide Salvage Pathways For Dna Synthesis In Skin
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چکیده
منابع مشابه
Pyrimidine nucleotide synthesis in the normal and hypertrophying rat heart. Relative importance of the de novo and "salvage" pathways.
Radioactive orotic acid incorporation into RNA (de novo pathway of pyrimidine nucleotide synthesis) was considerably lower for rat heart than for rat liver in vivo and in vitro. H uridine ("salvage" pathway) was incorporated into heart RNA to a greater extent than H orotic acid, and the labeling with uridine in the heart exceeded that in the liver. Extracts of heart showed little enzymatic conv...
متن کاملPurine and pyrimidine nucleotide synthesis and metabolism.
1. Abstract 2. Introduction 3. Purine and pyrimidine metabolism during somatic embryogenesis 3.1. Maintenance of embryogenic tissue 3.1.1. Purine metabolism during maintenance of embryogenic tissue 3.1.2. Pyrimidine metabolism during maintenance of embryogenic tissue 3.2. Development of somatic embryos 3.2.1. Purine metabolism during development of somatic embryos 3.2.2. Pyrimidine metabolism d...
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The use of stable isotope labeling has revolutionized NMR studies of nucleic acids, and there is a need for methods of incorporation of specific isotope labels to facilitate specific NMR experiments and applications. Enzymatic synthesis offers an efficient and flexible means to synthesize nucleoside triphosphates from a variety of commercially available specifically labeled precursors, permitti...
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Nucleotide balance is critically important not only in replicating cells but also in quiescent cells. This is especially true in the nervous system, where there is a high demand for adenosine triphosphate (ATP) produced from mitochondria. Mitochondria are particularly prone to oxidative stress-associated DNA damage because nucleotide imbalance can lead to mitochondrial depletion due to low repl...
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We have found that the anaerobic protozoan parasite Giardia lamblia is incapable of de novo pyrimidine metabolism, as shown by its inability to incorporate orotate, bicarbonate, and aspartate into the pyrimidine nucleotide pool. Results from high performance liquid chromatography of pyrimidine and pyrimidine nucleoside pulse-labeled nucleotide pools and enzyme assays suggest that the parasite s...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1976
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12482292